Denervation suppresses gastric tumorigenesis
نویسندگان
چکیده
منابع مشابه
Denervation suppresses gastric tumorigenesis.
The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis. In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or l...
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Cyclin dependent kinases (CDKs) contribute to tumor development by initiating unscheduled cell division. As an atypical CDK, CDK5 has been traditionally viewed as a functional component in the central nervous system rather than in cell proliferation. Here for the first time, we identify a drama...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2014
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3009569